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Discovery & Approval
DRUG
Identify biochemical, cellular, pathophysiological mechanism that will be targeted
TARGET SELECTION
2
Choose a disease area
&
Define the therapeutic need
THERAPEUTIC CONCEPT
1
Drug discovery is a process that starting from: (Ng.R, 2003)
1. NG, R. 2005. Drug Discovery: Targets and Receptors. Drugs. John Wiley & Sons, Inc.
2. Hill, R., & Rang, H. P. (2013). Drug discovery and development : Technology in transition (2nd ed.). Edinburgh ; New York: Elsevier.
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5,000-10,000 drugs molecules being identified & studied
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Requires 436 millions
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only 1% chance the drug molecules being success moving onto the next step
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Tim requried: 3 years
A process from therapeutic concept to molecule.
Drug Discovery
Identify the potential targets and validate the molecular drug targets
TARGET VALIDATION
3
Scan thousands of potential compounds from natural sources that interact with the selected targets
<< High-throughput screening (HTS) is a useful strategy to obtain useful data on the biological activity of huge number of compunds
LEAD FINDING
4
Optimize the properties of the lead compunds such as designing, testing, and fine tuning of the drug molecule to the point where it is deemed suitable for development.
LEAD OPTIMIZATION
5
Pre-clinical Development
Peform drug development and pre-clinical studies (in vitro and in vivo)
6
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